11 Best Brain Supplements to Fight Brain Fog and Improve Cognitive Health

Maintaining optimal brain health is more important than ever in today’s fast-paced world. Our cognitive abilities are crucial to our overall well-being and quality of life.

However, factors such as stress, poor diet, and lack of sleep can all contribute to cognitive decline, making it essential to pay attention to our mental health. That’s where brain supplements come in. These powerful agents can help support cognitive function and improve brain health, allowing us to stay sharp and focused throughout the day.

In this article, we’ll delve into the science behind some of the most effective brain supplements on the market. From omega-3 fatty acids to ginkgo biloba, we’ll explore how these powerful ingredients can help support healthy brain function and overall well-being.

Understanding Brain Health

Brain health refers to the well-being of cognitive and emotional functions, encompassing components such as memory, focus, processing speed, decision-making, and learning.

Optimal brain health enables clear thinking and emotional stability, while poor brain health can lead to depression, mood disorders, cognitive decline, and degenerative brain disorders.

Healthy lifestyle habits, including a balanced diet, regular physical activity, and engaging in mental activities for cognitive stimulation, all support brain health. By prioritizing brain function, we can enhance our cognitive abilities and lead a more fulfilling life.

The Impact of Poor Brain Health

Poor brain health can significantly impact daily life and overall well-being, leading to memory loss, reduced cognitive function, and conditions like dementia or Alzheimer’s.

Factors such as age, lifestyle, and genetics contribute to poor brain health, and impaired cognitive abilities can hinder daily tasks, work, studies, and relationships.

Furthermore, poor brain health can lower the quality of life and increase the risk of developing other health issues like depression or anxiety. Prioritizing brain health and adopting healthy lifestyle habits are essential for maintaining cognitive function and well-being.

Can Supplements Really Boost Brain Health?

Scientific research suggests brain supplements can promote cognitive function and enhance brain health.

However, efficacy may vary based on individual factors, and some supplements may have limitations or side effects. A personalized approach to brain supplement use is essential, and consulting with a physician before starting any new regimen is crucial to ensure safety and appropriateness based on individual needs, medical history, and potential drug interactions.

Top 11 Best Brain Supplements That May Enhance Cognitive Function

Here is a complete list of supplements supported by research for enhancing the function of brain cells & cognitive performance:

Omega-3 Fatty Acids

Omega-3 fatty acids, known for their anti-inflammatory properties, are crucial in brain development and cardiovascular health. By incorporating a high dose of DHA (900 mg), these essential fats may contribute to enhanced cognitive function. In healthy elderly individuals, this increased intake of Omega-3s could potentially slow cognitive decline, further supporting overall brain health. [1]

B Vitamins

B vitamins, specifically folate, vitamin B6, and B12, have been linked to enhanced cognitive function. Research indicates that these essential nutrients may contribute to slowing cognitive decline in individuals without dementia, with trials over 12 months showing promising results. Furthermore, folate has been associated with a reduced risk of developing dementia.[2] Evidence also suggests that nutritional interventions can improve cognitive performance in malnourished children, while increased fatty fish intake benefits healthy children. [3]


Blueberries, rich in antioxidant compounds called anthocyanins, are known for their cognitive-enhancing properties. These powerful molecules not only support cardiovascular wellness and liver health but also contribute to improved brain function. With their high antioxidant and anthocyanin content, blueberries have demonstrated benefits to promote brain health for individuals with cognitive decline, and animal studies suggest potential advantages for young, healthy individuals too. [4][5]


Caffeine, a well-known nootropic, is recognized for its ability to sensitize neurons and provide mental stimulation. This potent substance effectively enhances cognitive function by improving reaction time, though the effects may vary depending on the context. Additionally, caffeine is adept at promoting alertness and warding off drowsiness, contributing to better overall focus and concentration. Furthermore, regular caffeine consumption has been shown to lower the likelihood of developing Alzheimer’s disease. [6][7]


L-theanine, when supplemented alongside caffeine, can effectively enhance cognitive function. This amino acid has the unique ability to mitigate caffeine-induced over-excitability without diminishing its stimulatory impact. The synergistic pairing of caffeine and L-theanine works wonders in bolstering concentration, leading to improved focus and a longer attention span. [8]

Gingko Biloba

Research indicates that Ginkgo biloba may enhance cognitive functions in people with dementia. [9] Initial findings also suggest potential cognitive performance benefits for healthy middle-aged and older individuals. [10][11]

Rhodiola Rosea

Rhodiola Rosea’s adaptogenic qualities deliver numerous advantages like diminished brain fog, stress, and fatigue. It also bolsters mental performance, especially in high-pressure situations, enhancing cognitive function.[12]

Bacopa Monnieri

Bacopa monnieri is an herb known for its cognitive benefits and longevity support in traditional medicine. Research indicates that taking this herb can improve memory, especially in the short term, and provide mental health benefits. Studies have shown that it can enhance various memory types, including working memory, in healthy individuals and those with cognitive decline.[13]


Phosphatidylserine (PS) is a fat-soluble compound that is an amino acid derivative. It is found in the brain and contributes to cognitive functioning. Fish is a good source of PS and may improve memory in the elderly while lowering cortisol levels. Studies suggest that daily phosphatidylserine supplements in the 15-50mg/kg range can help slow down or reverse cognitive decline in aging rats. [14]

Lion’s Mane Mushroom

Clinical research has shown that Lion’s Mane Mushroom might help prevent cognitive decline in rats due to β-amyloid pigmentation. In human studies, consuming 3g of 98% Lion’s Mane powder in capsule form has resulted in marked enhancements on dementia rating scales for people facing overall cognitive decline. [15]


Taking cholinergics can increase the levels of acetylcholine in the brain, which may improve muscle strength and contractions, reflexes, and possibly learning capacity.

Frequently Asked Questions about Brain Supplements

Common inquiries include whether brain supplements truly work, if they are safe to consume, whether they can be taken during pregnancy or nursing, and if there are any side effects associated with brain health supplements.

The answers to these questions vary depending on the specific supplement and its ingredients. Some supplements, such as the ones listed above, have been shown to improve cognitive function, while others may not have substantial evidence supporting their claims.

Generally, brain supplements are considered safe, but it’s essential to consult a healthcare professional before use, especially during pregnancy or nursing. Side effects, if any, tend to be mild and depend on the individual and the supplement.

Practical Tips for Boosting Brain Health

Boosting brain health can be achieved through a combination of practical tips. A balanced diet is crucial in supporting healthy brain function, with the optimal nutrient intake of iodine, copper, zinc, vitamins B1, B3, B12, and folic acid being essential. Supplementation may be advised if dietary intake is insufficient.

Regular physical activity & movement contributes to overall well-being and cognitive function, while mental stimulation and cognitive training help keep the brain sharp and adaptive.

Finally, ensuring adequate rest and effective stress management is vital for nervous system regulation, allowing for optimal brain power and maintaining long-term health.


In conclusion, brain supplements offer a range of potential benefits, from enhancing cognitive function & mental clarity to supporting long-term brain health. However, it is crucial to consult a physician for a personalized approach, as individual needs and circumstances may vary.

We can optimize our mental performance and have a higher quality of life by prioritizing brain health as an overall wellness strategy.

Embracing a comprehensive approach that includes a balanced diet, regular movement, mental stimulation, and stress management can help ensure the best possible outcomes for a healthy and well-functioning brain.


[1] Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M; MIDAS Investigators. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010 Nov;6(6):456-64. doi: 10.1016/j.jalz.2010.01.013. PMID: 20434961.

[2] Wang Z, Zhu W, Xing Y, Jia J, Tang Y. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis. Nutr Rev. 2022 Mar 10;80(4):931-949. doi: 10.1093/nutrit/nuab057. PMID: 34432056.

[3] Roberts M, Tolar-Peterson T, Reynolds A, Wall C, Reeder N, Rico Mendez G. The Effects of Nutritional Interventions on the Cognitive Development of Preschool-Age Children: A Systematic Review. Nutrients. 2022 Jan 26;14(3):532. doi: 10.3390/nu14030532. PMID: 35276891; PMCID: PMC8839299.

[4] Hein S, Whyte AR, Wood E, Rodriguez-Mateos A, Williams CM. Systematic Review of the Effects of Blueberry on Cognitive Performance as We Age. J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):984-995. doi: 10.1093/gerona/glz082. PMID: 30941401.

[5] Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010 Apr 14;58(7):3996-4000. doi: 10.1021/jf9029332. PMID: 20047325; PMCID: PMC2850944.

[6] Adan A, Serra-Grabulosa JM. Effects of caffeine and glucose, alone and combined, on cognitive performance. Hum Psychopharmacol. 2010 Jun-Jul;25(4):310-7. doi: 10.1002/hup.1115. PMID: 20521321.

[7] Childs E, de Wit H. Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users. Psychopharmacology (Berl). 2006 May;185(4):514-23. doi: 10.1007/s00213-006-0341-3. Epub 2006 Mar 16. PMID: 16541243.

[8] Owen GN, Parnell H, De Bruin EA, Rycroft JA. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. 2008 Aug;11(4):193-8. doi: 10.1179/147683008X301513. PMID: 18681988.

[9] Hashiguchi M, Ohta Y, Shimizu M, Maruyama J, Mochizuki M. Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia. J Pharm Health Care Sci. 2015 Apr 10;1:14. doi: 10.1186/s40780-015-0014-7. PMID: 26819725; PMCID: PMC4729005.

[10] Kaschel R. Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers. Phytomedicine. 2011 Nov 15;18(14):1202-7. doi: 10.1016/j.phymed.2011.06.021. Epub 2011 Jul 30. PMID: 21802920.

[11] Mix JA, Crews WD Jr. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. Hum Psychopharmacol. 2002 Aug;17(6):267-77. doi: 10.1002/hup.412. PMID: 12404671.

[12] Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. doi: 10.1016/S0944-7113(00)80078-1. PMID: 10839209.

[13] Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008 Jul;14(6):707-13. doi: 10.1089/acm.2008.0018. PMID: 18611150; PMCID: PMC3153866.

[14] Calderini G, Aporti F, Bellini F, Bonetti AC, Teolato S, Zanotti A, Toffano G. Pharmacological effect of phosphatidylserine on age-dependent memory dysfunction. Ann N Y Acad Sci. 1985;444:504-6. doi: 10.1111/j.1749-6632.1985.tb37626.x. PMID: 3860111.

[15] Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634. PMID: 18844328.

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Dr. Linnea Passaler

Dr. Linnea Passaler

Dr. Linnea Passaler has dedicated 20+ years to serving patients, first to a small number of individuals as a successful surgeon and then to thousands of people worldwide as the CEO of a digital health startup. After overcoming her own struggles with a dysregulated nervous system, she created Heal Your Nervous System (HYNS) to empower others in their healing journey. Her combination of neuroscience and somatic work helps those struggling with overwhelm, trauma, burnout, and anxiety to heal their dysregulated nervous systems and thrive.