Your Ultimate Guide for Supplements to Lower Blood Sugar

Diabetes, a global health crisis of escalating proportions, is characterized by high blood sugar levels. According to the International Diabetes Federation, as of 2021, approximately 537 million adults were living with diabetes, and these numbers are projected to rise dramatically in the future. 

High blood sugar, if left unchecked, can lead to serious health risks, including heart disease, kidney damage, vision loss, and neuropathy, among others. Given the stakes, managing blood sugar levels is paramount to not only those diagnosed with diabetes but also to those with prediabetes or at high risk for the condition. 

Effective blood sugar control can significantly reduce the risk of complications, improve quality of life, and enhance overall health outcomes. That’s why the potential for dietary supplements to aid in blood sugar control has gained considerable interest. 

Supplementation, complementary to traditional treatments, explores the potential benefits of specific vitamins, minerals, and other nutrients in maintaining optimal blood glucose levels. It’s an exciting and promising area of diabetes management that merits further exploration and understanding, some of which we plan to instill via this blog.

Understanding Blood Sugar and Its Importance

Blood sugar, or glucose, is a crucial energy source for all body cells and organs. Dysregulated blood sugar levels, however, can lead to diabetes, a chronic condition often tied to insulin resistance. These glucose levels vary throughout the day, influenced by factors like food, physical activity, illness, and stress. 

For individuals without diabetes, normal glucose levels while fasting range between 70 to 99 mg/dL, postprandial (after meals) levels are less than 140 mg/dL, and random levels are usually less than 125 mg/dL. 

Abnormal or high glucose levels indicate prediabetes or diabetes. This includes fasting levels of 100-125 mg/dL for prediabetes and 126 mg/dL or higher for diabetes, postprandial levels of 140-199 mg/dL for prediabetes and 200 mg/dL or higher for diabetes, and random levels over 200 mg/dL for diabetes. The A1C test, reflecting 2-3 months of blood glucose control, is also utilized, with results over 6.5% suggesting diabetes.

Common Causes of High Blood Sugar

Elevated blood sugar levels, a condition known as hyperglycemia, can be triggered by an array of factors. These may include:

Insulin Resistance

Insulin resistance, a critical factor in the development of type 2 diabetes, can be managed effectively with the help of targeted dietary supplements.

A significant contributor to this condition is metabolic syndrome, characterized by high blood sugar levels, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.

Exercise is also noteworthy as physical activity helps keep cells sensitive to insulin and maintains normal glucose metabolism.

Nonetheless, genetic factors play an unalterable role in determining individual susceptibility to insulin resistance, but these can be mitigated with lifestyle and dietary changes.

Poor Diet And Lifestyle Choices

The role of poor diet and lifestyle choices in escalating blood sugar levels cannot be underestimated. A significant component of this is due to unhealthy snacking; frequent consumption of high-sugar, high-fat foods causes a surge in blood glucose levels, which over time may predispose you to conditions such as diabetes.

Concurrently, a sedentary lifestyle contributes to weight gain and amplifies the risk of developing insulin resistance, further worsening blood sugar levels.

Coupled with excessive alcohol consumption, liver disease is possible and function is altered, and has been associated with erratic blood glucose levels.

Stress And Other Health Conditions

Compounding the detrimental effects of poor dietary and lifestyle choices, stress and other health conditions often exacerbate blood glucose instability, underscoring a complex interplay between mental well-being, physiological states, and metabolic health.

Chronic stress elevates cortisol levels in the body which can disrupt insulin secretion and sensitivity. This emphasizes the need for effective stress management strategies to maintain healthy blood sugar levels.

Similarly, certain health conditions like obesity or polycystic ovary syndrome (PCOS) can lead to insulin resistance, further disrupting glucose metabolism.

Holistic therapies focusing on mental wellness alongside physical health are paramount in managing these influences on glycemic control. Such comprehensive approaches underscore the necessity not only for dietary supplements but also for adjunctive measures encompassing lifestyle modification for optimal metabolic regulation. 

Here at HYNS, our goal is to help you regain control over your body and manage the impact of stressors on your mental and physical health.

The Role Of Supplements In Blood Sugar Control

Supplements can exhibit varying actions in the manner in which they assist with blood glucose control. For example, some may improve your body’s utilization of glucose for energy.

Others may help reduce insulin resistance and associated symptoms of diabetes, such as neuropathy. Then there are others that have hypoglycemic actions comparable to some prescription medications and work to remove glucose from the blood. With that in mind, it is important to note that supplements are not devoid of possible adverse effects. Some are simply not safe – especially since the supplement industry is far less regulated than medication is. 

Additionally, not all supplements marketed for blood sugar control have been proven effective. Scientific studies on many supplements are mixed or inconclusive, and some products may be ineffective or even harmful. 

Supplements are not a one-size-fits-all solution, and their effectiveness can vary from person to person, depending on your individual health circumstances and genetic makeup.

That’s why it’s so crucial to consult a healthcare professional before starting any new supplement regimen. A healthcare provider can provide individualized advice based on your specific health status, your current medication regimen, and the latest scientific evidence. 

Most Effective Supplements To Lower Blood Sugar


Blood sugar regulation significantly benefits from incorporating fiber into one’s diet. Consumed from diverse sources like fruits, vegetables, whole grains, and legumes, fiber, specifically soluble fibers, decelerates the absorption of sugar, curbing post-meal glucose spikes [1]. 

Besides, fibers support a healthy gut microbiome, enhance satiety, and aid in weight management – all essential in managing diabetes or prediabetes. Fiber supplements, like psyllium husk, are common and assist in maintaining stable blood glucose levels for extended periods.


Magnesium, an abundant mineral in our bodies, influences blood glucose management. It affects insulin metabolism and glucose control, with research highlighting its role in promoting insulin sensitivity. Insulin allows glucose from our food to be used as energy or stored for future use, and magnesium facilitates the efficient uptake of glucose into cells. 

Consequently, inadequate magnesium can lead to insulin resistance, a common precursor to type 2 diabetes. Notably, poorly managed diabetes can cause a decrease in body magnesium levels, creating a detrimental cycle [2]. Therefore, adequate magnesium intake, from food or magnesium supplementation, is crucial for glucose control.


Zinc, an essential trace mineral, is pivotal in many biological processes, including blood glucose management. It’s integral to the body’s insulin metabolism, which directly impacts how your body regulates glucose. Zinc is involved in both the storage and secretion of insulin, promoting efficient glucose regulation [3]. 

Furthermore, zinc, as a cofactor for numerous enzymes, indirectly helps maintain balanced blood glucose levels. It also exhibits antioxidant properties, reducing oxidative stress linked to insulin resistance.


Cinnamon is a spice studied for its potential role in blood glucose management due to its supposed insulin-mimicking and insulin-sensitizing properties. Hydroxychalcone, its primary active compound, stimulates insulin receptors on cells and improves glucose uptake, potentially improving glycemic control. 

Cinnamon’s antioxidant properties may indirectly benefit blood glucose control by combating inflammation and oxidative stress, enhancing insulin sensitivity and glucose tolerance. Research indicates that cinnamon blood sugar supplements may lead to modest improvements in blood glucose levels, A1C [4], and insulin sensitivity, although results have been inconsistent.

Alpha-Lipoic Acid

Alpha-Lipoic Acid [5], a naturally occurring compound, has received attention for its potential in glucose management. Found in each cell of our bodies and in certain foods, ALA is crucial for converting glucose into energy. It influences insulin sensitivity, aiding the efficient uptake and utilization of glucose by cells, thereby potentially contributing to lower blood sugar levels. Additionally, ALA functions as a potent antioxidant, helping to neutralize free radicals, reduce oxidative stress, and mitigate the negative impacts on insulin function and overall metabolic health [5]. ALA may also aid in managing symptoms of diabetic neuropathy, a common diabetes complication characterized by nerve damage due to long-term high blood sugar levels.


Chromium, an essential trace mineral found in various foods, is key for processing carbohydrates, proteins, and fats, and it has potential benefits in blood glucose management. It enhances insulin action, helping increase glucose uptake into cells, reducing blood glucose levels and insulin resistance [6]. Studies indicate chromium supplementation, specifically chromium picolinate, could improve glycemic control and reduce fasting blood glucose and HbA1c levels.


Berberine, a bioactive compound used in traditional Chinese and Ayurvedic medicine, has potential benefits in metabolic health, including blood glucose management. It works by increasing insulin sensitivity and promoting glycolysis, leading to lowering blood sugar levels. 

It also slows carbohydrate breakdown in the gut, reducing post-meal glucose spikes. Clinical trials suggest that berberine is effective in reducing fasting blood sugar and A1C levels, similar to some oral diabetes drugs [7].


Inositol, a carbohydrate also known as vitamin B8, plays a crucial role in insulin signaling and glucose uptake. People with insulin resistance often have impaired inositol signaling, contributing to elevated blood glucose levels. Inositol supplementation, especially D-chiro-inositol, improves insulin sensitivity and decreases blood glucose levels. It also benefits those with polycystic ovary syndrome (PCOS), a condition often linked to insulin resistance [8].

Vitamin C

Vitamin C, traditionally known for boosting immunity, can also help regulate blood sugar levels. It enhances the functioning of the GLUT4 transporter, a protein that moves glucose into cells and reduces oxidative stress, which contributes to insulin resistance. By decreasing oxidative stress, vitamin C can improve insulin sensitivity.


Glycine, a non-essential amino acid, plays a role in maintaining and managing blood glucose levels. It aids in the production of glucagon, a hormone that raises blood glucose levels when they are low and is thought to improve insulin sensitivity, preventing insulin resistance.


Apple cider vinegar, containing the primary active component acetic acid, can help lower blood sugar levels by improving insulin sensitivity, particularly after high-carbohydrate meals [9]. Vinegar may slow carbohydrate digestion, reducing the rate at which sugars enter the bloodstream, leading to more gradual blood sugar levels. It may also enhance insulin effectiveness, enabling better glucose absorption and use for energy, resulting in lower blood glucose levels.

Frequently Asked Questions about Supplements and Blood Sugar

Can Supplements Cure Diabetes?

As of now, there is no known cure for diabetes, and that includes via the use of supplements. While some supplements have shown promise in aiding blood sugar control and improving insulin sensitivity, they should be viewed as a component of a comprehensive management plan rather than a cure. Supplements can potentially complement an otherwise effective plan, but they are not a standalone solution. 

Are There Risks Associated With Using Supplements For Blood Sugar Control?

Yes, there can be risks associated with using supplements for blood sugar control. Some supplements can interact with medications you’re already taking, possibly leading to adverse effects. For instance, certain supplements can affect how your body processes medication, potentially making the medication less effective or increasing its potency, which can be dangerous. Some supplements may also have side effects of their own, particularly when taken in large doses.

How Quickly Can Supplements Impact Blood Sugar Levels?

The speed at which supplements might impact blood sugar levels varies widely and depends on numerous factors, including the type of supplement, your overall diet and health status, and your individual biological response. Some people may notice a difference within a few weeks of starting a supplement, while for others it might take several months. It’s also important to remember that supplements may not have a noticeable impact on blood sugar levels for everyone.

Can I Stop My Conventional Medication If Supplements Work For Me?

It’s essential to consult with your healthcare provider before making any changes to your medication regimen, including if you feel that a supplement is helping you manage your blood sugar. 

While it’s encouraging if a supplement appears to be helping, it should not be used as a reason to stop taking prescribed medication without the advice of a healthcare professional. Diabetes medications are designed to help control blood sugar levels over the long term, and abruptly stopping them could lead to serious health consequences. 


Supplements like chromium, berberine, inositol, vitamin C, glycine, and vinegar can play a significant role in managing blood glucose levels. They can enhance insulin sensitivity, promote glucose uptake, and reduce carbohydrate breakdown, all contributing to better blood sugar control. 

However, it’s crucial to remember that supplements are just one piece of the puzzle. A holistic approach, encompassing a balanced diet, regular physical activity, stress management, and adequate sleep, is fundamental to managing blood glucose effectively. 

Furthermore, each individual’s needs and responses may vary, and what works for one person may not work for another. Therefore, before initiating any supplement regimen, it is always important to consult a healthcare professional. They can provide personalized advice based on one’s health history and lifestyle, ensuring the most effective and safest approach to managing blood sugar levels.


[1] Weickert, M. O., & Pfeiffer, A. F. (2008). Metabolic effects of dietary fiber consumption and prevention of diabetes. The Journal of nutrition138(3), 439–442.

[2] Pham, P. C., Pham, P. M., Pham, S. V., Miller, J. M., & Pham, P. T. (2007). Hypomagnesemia in patients with type 2 diabetes. Clinical journal of the American Society of Nephrology : CJASN, 2(2), 366–373.

[3] Ranasinghe, P., Pigera, S., Galappatthy, P., Katulanda, P., & Constantine, G. R. (2015). Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 23(1), 44.

[4] Crawford P. (2009). Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. Journal of the American Board of Family Medicine : JABFM, 22(5), 507–512.

[5] Porasuphatana, S., Suddee, S., Nartnampong, A., Konsil, J., Harnwong, B., & Santaweesuk, A. (2012). Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pacific journal of clinical nutrition, 21(1), 12–21.

[6] Hua, Y., Clark, S., Ren, J., & Sreejayan, N. (2012). Molecular mechanisms of chromium in alleviating insulin resistance. The Journal of nutritional biochemistry, 23(4), 313–319.

[7] Dong, H., Wang, N., Zhao, L., & Lu, F. (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-based complementary and alternative medicine : eCAM, 2012, 591654.

[8] Miñambres, I., Cuixart, G., Gonçalves, A., & Corcoy, R. (2019). Effects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trials. Clinical nutrition (Edinburgh, Scotland), 38(3), 1146–1152.

[9] Shishehbor, F., Mansoori, A., & Shirani, F. (2017). Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials. Diabetes research and clinical practice, 127, 1–9.

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Dr. Linnea Passaler

Dr. Linnea Passaler

Dr. Linnea Passaler has dedicated 20+ years to serving patients, first to a small number of individuals as a successful surgeon and then to thousands of people worldwide as the CEO of a digital health startup. After overcoming her own struggles with a dysregulated nervous system, she created Heal Your Nervous System (HYNS) to empower others in their healing journey. Her combination of neuroscience and somatic work helps those struggling with overwhelm, trauma, burnout, and anxiety to heal their dysregulated nervous systems and thrive.